In accordance with Item 402(x)of Regulation S-K, we are providing information regarding our practices related to the grant of stock options, stock appreciation rights, or similar option-like instruments close in time to the release of material non-public information. It is not our policy to time the release of material nonpublic information for the purpose of affecting the value of executive compensation or to take material nonpublic information into account when determining the timing and terms of such awards. Although we do not have a formal policy with respect to the timing of our equity award grants, our board of directors or Compensation Committee has historically granted such awards on a predetermined annual schedule, which includes annual equity awards granted in January of each year. Equity grants may also be made on other dates in connection with new hires, promotions, or similar events. .

The grant date of SARs to Dr. Nguyen was scheduled in connection with the hiring of Dr. Nguyen effective February 24, 2025, but on the same day we filed a Current Report on Form 8-K reporting the retirement of Dr. Kenneth Johnson, our former Senior Vice President, Global Development and Medical Affairs, and appointment of Dr. Nguyen on February 24, 2025. In accordance with the requirements of the SEC, the following table discloses additional information with respect to the stock appreciation rights that we awarded to Dr. Nguyen on February 24, 2025.

Name

Grant Date

Number of Securities Underlying the Award

Exercise Price of the Award ($/Sh)

Grant Date Fair Value of the Award(1)

Percentage Change in the Closing Market Price of the Securities Underlying the Award Between the Trading Day Ending Immediately Prior to the Disclosure of Material, Nonpublic Information and the Trading Day Beginning Immediately following the Disclosure of Material, Nonpublic Information (%)(2)

(a)

(b)

(c)

(d)

(e)

(f)

Anh T. Nguyen

2/24/2025

150,000

3.76

$218,945

1.86

(1) The amount reported in this column reflects the grant date fair value of the stock appreciation right as determined under the principles used to calculate the grant date fair value of equity awards for purposes of our financial statements in accordance with ASC 718. For a discussion of the assumptions and methodologies used to value the award, please see the discussion of option awards contained in the notes to the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the SEC on March 2, 2026.

(2) Represents the percentage change in the closing price of our common stock between the trading day ending immediately prior to the disclosure of material nonpublic information (a closing price of $3.76 on February 24, 2025) and the trading day beginning immediately following the disclosure of material nonpublic information (a closing price of $3.83 on February 28, 2025). We have assumed for purposes of this table that the Form 8-K filed with the SEC on the grant date as including material nonpublic information for purposes of this table.

Award Timing Predetermined

true

Award Timing, How MNPI Considered

It is not our policy to time the release of material nonpublic information for the purpose of affecting the value of executive compensation or to take material nonpublic information into account when determining the timing and terms of such awards. Although we do not have a formal policy with respect to the timing of our equity award grants, our board of directors or Compensation Committee has historically granted such awards on a predetermined annual schedule, which includes annual equity awards granted in January of each year. Equity grants may also be made on other dates in connection with new hires, promotions, or similar events. .

Awards Close in Time to MNPI Disclosures, Table

Name

Grant Date

Number of Securities Underlying the Award

Exercise Price of the Award ($/Sh)

Grant Date Fair Value of the Award(1)

Percentage Change in the Closing Market Price of the Securities Underlying the Award Between the Trading Day Ending Immediately Prior to the Disclosure of Material, Nonpublic Information and the Trading Day Beginning Immediately following the Disclosure of Material, Nonpublic Information (%)(2)

(a)

(b)

(c)

(d)

(e)

(f)

Anh T. Nguyen

2/24/2025

150,000

3.76

$218,945

1.86

(1) The amount reported in this column reflects the grant date fair value of the stock appreciation right as determined under the principles used to calculate the grant date fair value of equity awards for purposes of our financial statements in accordance with ASC 718. For a discussion of the assumptions and methodologies used to value the award, please see the discussion of option awards contained in the notes to the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the SEC on March 2, 2026.

(2) Represents the percentage change in the closing price of our common stock between the trading day ending immediately prior to the disclosure of material nonpublic information (a closing price of $3.76 on February 24, 2025) and the trading day beginning immediately following the disclosure of material nonpublic information (a closing price of $3.83 on February 28, 2025). We have assumed for purposes of this table that the Form 8-K filed with the SEC on the grant date as including material nonpublic information for purposes of this table.

Awards Close in Time to MNPI Disclosures

Underlying Securities | shares

150,000

Fair Value as of Grant Date | $

$ 218,945