v3.26.1
Segment and Geographic Information
 6 Months Ended
Jun. 30, 2026
Segment Reporting [Abstract]  
Segment and Geographic Information Segment and Geographic Information
Operating segments are defined as components of an entity about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company currently operates in two business segments, which are U.S. and international segments for the development and commercialization of therapies for patients with rare diseases. A single management team that reports to the Chief Executive Officer who comprehensively manages the entire business. The Company meets the aggregation criteria of ASC 280 and therefore has one reportable segment for the six months ended June 30, 2026 and June 30, 2025.
The table below is a summary of the segment profit or loss, including significant segment expenses (in thousands):
Three months ended June 30,Six months ended June 30,
2026202520262025
Net product revenue - U.S.$50,987 $31,982 $87,883 $56,352 
Net product revenue - International20,268 16,520 43,484 29,868 
Total net product revenue 71,255 48,502 131,367 86,220 
License revenue- - — (5,014)
Total revenue, net 71,255 48,502 131,367 81,206 
Cost of sales8,931 5,543 16,088 9,191 
Global headcount expense 59,446 39,892 118,100 74,760 
Preclinical, clinical and development expense 20,311 22,946 38,822 42,906 
Commercial & medical affairs 21,879 17,030 42,143 30,279 
Corporate, general & administrative 9,240 8,387 17,127 16,370 
Other income (expense), net1,018 1,576 (686)932 
Interest income (expense), net(1,320)(2,575)(2,349)(4,345)
Income taxes 444 337 989 417 
Net loss $(49,298)$(46,632)$(104,937)$(96,130)
Geographic Data
The Company allocates, for the purpose of geographic data reporting, its revenue based upon the location of its customers. Total product revenue, net, by geographic area was as follows (in thousands):
Three months ended June 30,Six months ended June 30,
2026202520262025
US $50,987 $31,982 $87,883 $56,352 
International20,268 16,520 43,484 29,868 
Total product revenue, net$71,255 $48,502 $131,367 $86,220 
As of June 30, 2026 and December 31, 2025, long-lived assets at locations outside the United States were not material.