| Schedule of segment profit or loss, including significant segment expenses |
The table below is a summary of the segment profit or loss, including significant segment expenses (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | Three months ended June 30, | | Six months ended June 30, | | 2026 | | 2025 | | 2026 | | 2025 | | Net product revenue - U.S. | $ | 50,987 | | | $ | 31,982 | | | $ | 87,883 | | | $ | 56,352 | | | Net product revenue - International | 20,268 | | | 16,520 | | | 43,484 | | | 29,868 | | | Total net product revenue | 71,255 | | | 48,502 | | | 131,367 | | | 86,220 | | | License revenue | - | | | - | | | — | | | (5,014) | | | Total revenue, net | 71,255 | | | 48,502 | | | 131,367 | | | 81,206 | | | | | | | | | | | Cost of sales | 8,931 | | | 5,543 | | | 16,088 | | | 9,191 | | | Global headcount expense | 59,446 | | | 39,892 | | | 118,100 | | | 74,760 | | | Preclinical, clinical and development expense | 20,311 | | | 22,946 | | | 38,822 | | | 42,906 | | | Commercial & medical affairs | 21,879 | | | 17,030 | | | 42,143 | | | 30,279 | | | Corporate, general & administrative | 9,240 | | | 8,387 | | | 17,127 | | | 16,370 | | | Other income (expense), net | 1,018 | | | 1,576 | | | (686) | | | 932 | | | Interest income (expense), net | (1,320) | | | (2,575) | | | (2,349) | | | (4,345) | | | Income taxes | 444 | | | 337 | | | 989 | | | 417 | | | Net loss | $ | (49,298) | | | $ | (46,632) | | | $ | (104,937) | | | $ | (96,130) | |
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| Schedule of revenue by geographic area |
The Company allocates, for the purpose of geographic data reporting, its revenue based upon the location of its customers. Total product revenue, net, by geographic area was as follows (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | Three months ended June 30, | | Six months ended June 30, | | 2026 | | 2025 | | 2026 | | 2025 | | US | $ | 50,987 | | | $ | 31,982 | | | $ | 87,883 | | | $ | 56,352 | | | International | 20,268 | | | 16,520 | | | 43,484 | | | 29,868 | | | Total product revenue, net | $ | 71,255 | | | $ | 48,502 | | | $ | 131,367 | | | $ | 86,220 | |
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